H2N2V1, Main, Exploration, bibRecord, 002246

Limiting dilution analysis of memory cytotoxic T lymphocytes specific for individual influenza virus gene products

Identifieur interne : 002246 ( Main/Exploration ); précédent : 002245; suivant : 002247

Limiting dilution analysis of memory cytotoxic T lymphocytes specific for individual influenza virus gene products

Auteurs : Maria Wysocka [États-Unis] ; Jack R. Bennink [États-Unis]

Source :

Cellular Immunology [ 0008-8749 ] ; 1988.

RBID : ISTEX:9AFFB15197DC46DA1EE5A7E3B27B519C1CFEF2D5

Descripteurs français

English descriptors

KwdEn :
- Animals, Cytotoxicity Tests, Immunologic (methods), Genes, Viral, Immunologic Memory, Influenza A virus (genetics), Influenza A virus (immunology), Leukocyte Count, Mice, Mice, Inbred BALB C, Nucleoproteins (genetics), Nucleoproteins (immunology), RNA-Binding Proteins, T-Lymphocytes, Cytotoxic (classification), T-Lymphocytes, Cytotoxic (immunology), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology), Viral Core Proteins, Viral Proteins (genetics), Viral Proteins (immunology).
MESH :
- chemical , genetics : Nucleoproteins, Vaccines, Synthetic, Viral Proteins.
- classification : T-Lymphocytes, Cytotoxic.
- genetics : Influenza A virus.
- immunology : Influenza A virus, Nucleoproteins, T-Lymphocytes, Cytotoxic, Vaccines, Synthetic, Viral Proteins.
- methods : Cytotoxicity Tests, Immunologic.
Teeft :
- Acidic polymerase, Animals, Authentic influenza virus proteins, Basic polymerase, Clone, Confidence range probability, Cytotoxic, Dilution cultures, Gene products, Genes, Viral, Hemagglutinin, Imdm, Immunol, Immunologic Memory, Individual influenza virus gene products, Influenza, Influenza cytotoxic, Influenza virus, Influenza viruses, Leukocyte Count, Lymphocyte, Lysing, Lysing target cells, Matrix, Mice, Mice, Inbred BALB C, Nonstructural, Palese, Polymerase, Pr8i, Previous studies, RNA-Binding Proteins, Recombinant, Recombinant vaccinia viruses, Recombinant vacs, Restimulated, Short communications, Short communications table, Sodium dodecyl, Splenocytes, Splenocytes restimulated, Stimulator cells, Target cells, Vaccinia, Vaccinia virus, Viral, Viral Core Proteins.

Abstract

Abstract: The frequency of memory T cells specific for individual influenza virus gene products in the spleens of BALB/c mice primed with A/Puerto Rico/8/34/1(H1N1) (PR8) influenza A virus was determined by using limiting dilution protocols. The results confirm that the influenza virus nucleoprotein (NP) is the predominant protein recognized by BALB/c cytotoxic T lymphocyte (CTL). This was true whether the responder splenocytes were restimulated with homologous PR8 virus or heterologous A/Japan/305/57 (H2N2) (JAP). The frequency hierarchy for BALB/c splenocytes restimulated with PR8 was NP > PB2 ⩾ H1 > NS1 > H2. The frequency of CTL specific for all other influenza gene products was too low to calculate. The CTL hierarchy for BALB/c splenocytes restimulated with JAP was NP > NS1, with all others lower than 1 in 96,000.

Url:

https://api.istex.fr/ark:/67375/6H6-91W9BDJS-9/fulltext.pdf

DOI: 10.1016/0008-8749(88)90311-5

Affiliations:

Le document en format XML

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<term>Immunologic Memory</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (immunology)</term>
<term>Leukocyte Count</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Nucleoproteins (genetics)</term>
<term>Nucleoproteins (immunology)</term>
<term>RNA-Binding Proteins</term>
<term>T-Lymphocytes, Cytotoxic (classification)</term>
<term>T-Lymphocytes, Cytotoxic (immunology)</term>
<term>Vaccines, Synthetic (genetics)</term>
<term>Vaccines, Synthetic (immunology)</term>
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<term>Viral Proteins (genetics)</term>
<term>Viral Proteins (immunology)</term>
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<term>Gènes viraux</term>
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<term>Lymphocytes T cytotoxiques (immunologie)</term>
<term>Mémoire immunologique</term>
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<term>Nucléoprotéines (immunologie)</term>
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<term>Protéines de liaison à l'ARN</term>
<term>Protéines du core viral</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Tests de cytotoxicité immunologique ()</term>
<term>Vaccins synthétiques (génétique)</term>
<term>Vaccins synthétiques (immunologie)</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (immunologie)</term>
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<term>Virus de la grippe A</term>
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<term>Protéines virales</term>
<term>Vaccins synthétiques</term>
<term>Virus de la grippe A</term>
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<term>Authentic influenza virus proteins</term>
<term>Basic polymerase</term>
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<term>Palese</term>
<term>Polymerase</term>
<term>Pr8i</term>
<term>Previous studies</term>
<term>RNA-Binding Proteins</term>
<term>Recombinant</term>
<term>Recombinant vaccinia viruses</term>
<term>Recombinant vacs</term>
<term>Restimulated</term>
<term>Short communications</term>
<term>Short communications table</term>
<term>Sodium dodecyl</term>
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<term>Splenocytes restimulated</term>
<term>Stimulator cells</term>
<term>Target cells</term>
<term>Vaccinia</term>
<term>Vaccinia virus</term>
<term>Viral</term>
<term>Viral Core Proteins</term>
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<term>Gènes viraux</term>
<term>Lymphocytes T cytotoxiques</term>
<term>Mémoire immunologique</term>
<term>Numération des leucocytes</term>
<term>Protéines de liaison à l'ARN</term>
<term>Protéines du core viral</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
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<front><div type="abstract" xml:lang="en">Abstract: The frequency of memory T cells specific for individual influenza virus gene products in the spleens of BALB/c mice primed with A/Puerto Rico/8/34/1(H1N1) (PR8) influenza A virus was determined by using limiting dilution protocols. The results confirm that the influenza virus nucleoprotein (NP) is the predominant protein recognized by BALB/c cytotoxic T lymphocyte (CTL). This was true whether the responder splenocytes were restimulated with homologous PR8 virus or heterologous A/Japan/305/57 (H2N2) (JAP). The frequency hierarchy for BALB/c splenocytes restimulated with PR8 was NP > PB2 ⩾ H1 > NS1 > H2. The frequency of CTL specific for all other influenza gene products was too low to calculate. The CTL hierarchy for BALB/c splenocytes restimulated with JAP was NP > NS1, with all others lower than 1 in 96,000.</div>
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Limiting dilution analysis of memory cytotoxic T lymphocytes specific for individual influenza virus gene products

Limiting dilution analysis of memory cytotoxic T lymphocytes specific for individual influenza virus gene products

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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